CONFORMATIONAL MAPPING OF AMYLOID PEPTIDES FROM THE PUTATIVE NEUROTOXIC 25-35 REGION

被引：22
|
作者：
LACZKO, I
HOLLY, S
KONYA, Z
SOOS, K
VARGA, JL
HOLLOSI, M
PENKE, B
机构：
[1] CENT RES INST CHEM, H-1525 BUDAPEST, HUNGARY
[2] SZENT GYORGYI MED UNIV, DEPT MED CHEM, H-6720 SZEGED, HUNGARY
[3] EOTVOS LORAND UNIV, DEPT ORGAN CHEM, H-1518 BUDAPEST, HUNGARY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期
关键词：
D O I：
10.1006/bbrc.1994.2638
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The secondary structure of amyloid beta A(25-35) and its deletion analogues was studied by circular dichroism (CD), Fourier transform infrared (FTIR) spectroscopy and molecular dynamics calculation. Data of our comparative CD and FTIR measurements in trifluoroethanol suggest that beta A(25-35)NH2 has a preferred beta-sheet conformation. Contrary to this beta A(31-35)NH2 tends to adopt a beta-turn conformation. Based on the comparable neurotoxic effect of beta A(25-35)NH2 and beta A(31-35)NH2 the neurotoxicity likely involves the same 31-35 core sequence and the ''biologically active conformation'' is a beta-turn rather than a beta-sheet structure. (C) 1994 Academic Press, Inc.
引用
收藏
页码：120 / 126
页数：7
相关论文
共 50 条
  • [1] Channel formation by a neurotoxic beta amyloid peptide, A beta 25-35
    Lin, MC
    Mirzabekov, T
    Kagan, B
    NEURODEGENERATIVE DISEASES: MOLECULAR AND CELLULAR MECHANISMS AND THERAPEUTIC ADVANCES, 1996, : 331 - 336
  • [2] Putative Pore Structures of Amyloid β 25-35 in Lipid Bilayers
    Dutta, Ankita
    Sepehri, Aliasghar
    Lazaridis, Themis
    BIOCHEMISTRY, 2023, 62 (17) : 2549 - 2558
  • [3] Synthesis and tritium labelling of β-amyloid(31-35) and β-amyloid(25-35) peptides
    Gulyás, EC
    Soós, K
    Varga, J
    Penke, B
    Tóth, G
    SYNTHESIS AND APPLICATIONS OF ISOTOPICALLY LABELLED COMPOUNDS 1997, 1998, : 467 - 470
  • [4] Influence of Au nanoparticles on the aggregation of amyloid-β-(25-35) peptides
    Ma, Qianqian
    Wei, Guanghong
    Yang, Xinju
    NANOSCALE, 2013, 5 (21) : 10397 - 10403
  • [5] INTRACEREBRAL BETA-AMYLOID(25-35) PRODUCES TISSUE-DAMAGE - IS IT NEUROTOXIC
    RUSH, DK
    ASCHMIES, S
    MERRIMAN, MC
    NEUROBIOLOGY OF AGING, 1992, 13 (05) : 591 - 594
  • [6] Nicotine modulates the neurotoxic effect of beta-amyloid protein((25-35)) in hippocampal cultures
    Zamani, MR
    Allen, YS
    Owen, GP
    Gray, JA
    NEUROREPORT, 1997, 8 (02) : 513 - 517
  • [7] Membrane perturbation by the neurotoxic Alzheimer amyloid fragment β25-35 requires aggregation and β-sheet formation
    Hirakura, Y
    Satoh, Y
    Hirashima, N
    Suzuki, T
    Kagan, BL
    Kirino, Y
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1998, 46 (04): : 787 - 794
  • [8] In vitro degradation of β-amyloid[25-35] peptide
    Jost, K
    Varga, J
    Penke, S
    Zarándi, M
    PROTEIN AND PEPTIDE LETTERS, 2001, 8 (06): : 423 - 428
  • [9] Transferrin neutralization of amyloid β 25-35 cytotoxicity
    Giunta, S
    Galeazzi, R
    Valli, MB
    Corder, EH
    Galeazzi, L
    CLINICA CHIMICA ACTA, 2004, 350 (1-2) : 129 - 136
  • [10] Conformational Preference of Aβ25-35 and Aβ35-25 Membrane Mimicking Environments
    Sambasivam, Dhandayuthapani
    Sivanesan, Senthilkumar
    Sultana, Sayeeda
    Rajadas, Jayakumar
    PROTEIN AND PEPTIDE LETTERS, 2019, 26 (05): : 386 - 390
12345