NEUTRALIZING ANTIBODIES TO INTERFERON-ALPHA - RELATIVE FREQUENCY IN PATIENTS TREATED WITH DIFFERENT INTERFERON PREPARATIONS

被引：200
作者：
ANTONELLI, G
CURRENTI, M
TURRIZIANI, O
DIANZANI, F
机构：
[1] Institute of Virology, University La Sapienza, 00185 Rome
来源：
JOURNAL OF INFECTIOUS DISEASES | 1991年 / 163卷 / 04期
关键词：
D O I：
10.1093/infdis/163.4.882
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The frequencies of antibody development so far reported in patients treated with different interferons (IFNs) are not readily comparable because of differences in treatment regimens and assay methods. Thus the frequency of neutralizing antibody development was analyzed in a large sample of sera derived from a relatively homogeneous group of patients treated with different IFN-alpha preparations. The frequency of developing neutralizing antibody to IFN varied according to the IFN given. Particularly, the seroconversion frequency was significantly higher in patients treated with recombinant IFN-alpha-2a (20.2%) than in patients treated with either recombinant IFN-alpha-2b (6.9%) or IFN-alpha-N1 (1.2%), a lymphoblastoid IFN-alpha. Furthermore, sera obtained from patients treated with either recombinant IFN neutralized both types of recombinant IFNs but failed to neutralize IFN-alpha-N1.
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页码：882 / 885
页数：4
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