THE MOUSE MODEL OF OXYGEN-INDUCED RETINOPATHY - A SUITABLE ANIMAL-MODEL FOR ANGIOGENESIS RESEARCH

被引：25
作者：
GOLE, GA [1 ]
BROWNING, J [1 ]
ELTS, SM [1 ]
机构：
[1] FLINDERS UNIV,DEPT OPHTHALMOL,BEDFORD PK,SA 5042,AUSTRALIA
来源：
DOCUMENTA OPHTHALMOLOGICA | 1990年 / 74卷 / 03期
关键词：
angiogenesis; mouse; oxygen-induced retinopathy; retinopathy of prematurity; ultrastructure;
D O I：
10.1007/BF02482605
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Newborn mice exposed to high (>98%) ambient oxygen during the newborn period and subsequently removed to room air will develop a proliferative retinopathy which mimics the neovascular component of acute retinopathy of prematurity. In this paper, we report preliminary ultrastructural findings on the vitreous new vessels in the mouse model of oxygen-induced retinopathy, and argue that the model is appropriate for research on non surgical treatments for ROP in particular and angiogenesis in general. © 1990 Kluwer Academic Publishers.
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页码：163 / 169
页数：7
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