COVALENT BINDING OF ACETAMINOPHEN TO MOUSE HEMOGLOBIN - IDENTIFICATION OF MAJOR AND MINOR ADDUCTS FORMED INVIVO AND IMPLICATIONS FOR THE NATURE OF THE ARYLATING METABOLITES

被引：48

作者：

AXWORTHY, DB ^{[1
]}

HOFFMANN, KJ ^{[1
]}

STREETER, AJ ^{[1
]}

CALLEMAN, CJ ^{[1
]}

PASCOE, GA ^{[1
]}

BAILLIE, TA ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH PHARM,DEPT MED CHEM,BG-20,SEATTLE,WA 98195

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1988年 / 68卷 / 1-2期

关键词：

D O I：

10.1016/0009-2797(88)90009-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：99 / 116

页数：18

共 37 条

[1]

ALBANO E, 1985, MOL PHARMACOL, V28, P306

[2] CONVERSION OF THE PROSTHETIC MOIETIES OF GLUTATHIONE PATHWAY CONJUGATES TO THE CORRESPONDING S-ACETATES [J].

BAKKE, JE .

BIOMEDICAL MASS SPECTROMETRY, 1982, 9 (02) :74-77

[3] LIVER NECROSIS FROM PARACETAMOL [J].

BOYD, EM ;

BERECZKY, GM .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 26 (03) :606-&

[4] SYNTHESIS, DECOMPOSITION KINETICS, AND PRELIMINARY TOXICOLOGICAL STUDIES OF PURE N-ACETYL-P-BENZOQUINONE IMINE, A PROPOSED TOXIC METABOLITE OF ACETAMINOPHEN [J].

DAHLIN, DC ;

NELSON, SD .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) :885-886

[5] N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].

DAHLIN, DC ;

MIWA, GT ;

LU, AYH ;

NELSON, SD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331

[6] RADICAL FORMATION DURING AUTOXIDATION OF 4-DIMETHYLAMINOPHENOL AND SOME PROPERTIES OF THE REACTION-PRODUCTS [J].

EYER, P ;

LENGFELDER, E .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (07) :1005-1013

[7]

EYER P, 1983, MOL PHARMACOL, V24, P282

[8]

FARMER PB, 1982, CHEM BRIT, V18, P790

[9]

FARMER PB, 1984, IARC SCI PUBL, V59, P189

[10] STUDIES ON THE MECHANISM OF TOXICITY OF ACETAMINOPHEN - SYNTHESIS AND REACTIONS OF N-ACETYL-2,6-DIMETHYL-PARA-BENZOQUINONE AND N-ACETYL-3,5-DIMETHYL-PARA-BENZOQUINONE IMINES [J].

FERNANDO, CR ;

CALDER, IC ;

HAM, KN .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) :1153-1158

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