MUTATION IN THE MITOCHONDRIAL TRNA(LEU) AT POSITION-3243 AND SPONTANEOUS-ABORTIONS IN JAPANESE WOMEN ATTENDING A CLINIC FOR DIABETIC PREGNANCIES

被引：28

作者：

YANAGISAWA, K

UCHIGATA, Y

SANAKA, M

SAKURA, H

MINEI, S

SHIMIZU, M

KANAMURO, R

KADOWAKI, T

OMORI, Y

机构：

[1] TOKYO WOMENS MED COLL, CTR DIABET, SHINJUKU KU, TOKYO 162, JAPAN

[2] UNIV TOKYO, DEPT INTERNAL MED 3, TOKYO 113, JAPAN

来源：

DIABETOLOGIA | 1995年 / 38卷 / 07期

关键词：

MITOCHONDRIAL DNA MUTATION; INSULIN-DEPENDENT DIABETES MELLITUS; NON-INSULIN-DEPENDENT DIABETES MELLITUS; GESTATIONAL DIABETES MELLITUS;

D O I：

10.1007/s001250050357

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitochondrial DNA is exclusively maternally inherited. We recently found the prevalence of diabetic patients with an A to G transition at position 3243 of leucine tRNA (3243 base pair (bp) mutation) to be nearly 1 % in randomly selected Japanese subjects. Here, we report the higher prevalence of diabetic patients with the 3243 bp mutation in a specific Japanese population of women attending a diabetic pregnancy clinic. Of 102 patients with non-insulin-dependent diabetes mellitus 6 (5.9 %) were positive for the mutation, 1 (8.3 %) of 12 patients with gestational diabetes and 2 (5.9 %) out of 34 borderline diabetic patients. In contrast, none of 64 patients (0 %) with insulin-dependent diabetes mellitus had the 3243 bp mutation. Moreover, there was a difference in the prevalence of spontaneous abortions between patients with and without this mutation (27.3 vs 12.4 %). Among nine probands with the mutation, four had a history of one spontaneous abortion (p = 0.0518) and two had a history of two abortions (p = 0.0479). Two probands had a spontaneous abortion even while under strict diabetic metabolic control. The 3243 bp mutation thus may cause spontaneous abortion during pregnancy.

引用

页码：809 / 815

页数：7

共 29 条

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