AN ANATOMICAL CASCADE HYPOTHESIS FOR ALZHEIMERS-DISEASE

被引：73

作者：

HARDY, J

机构：

[1] Dept of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London

来源：

TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 06期

关键词：

D O I：

10.1016/0166-2236(92)90033-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The molecular mechanisms of the cytopathology of Alzheimer's disease are very rapidly being elucidated However, the factors that restrict the effects of this disease to specific neuroanatomical systems are less well understood. In this brief article a possible hypothesis is outlined to explain this apparent specific localization.

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页码：200 / 201

页数：2

相关论文

共 26 条

[11] PRECURSOR OF AMYLOID PROTEIN IN ALZHEIMER-DISEASE UNDERGOES FAST ANTEROGRADE AXONAL-TRANSPORT [J].

KOO, EH ;

SISODIA, SS ;

ARCHER, DR ;

MARTIN, LJ ;

WEIDEMANN, A ;

BEYREUTHER, K ;

FISCHER, P ;

MASTERS, CL ;

PRICE, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1561-1565

[12] THE PATTERN OF ACQUISITION OF PLAQUES AND TANGLES IN THE BRAINS OF PATIENTS UNDER 50 YEARS OF AGE WITH DOWNS-SYNDROME [J].

MANN, DMA ;

ESIRI, MM .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1989, 89 (2-3) :169-179

[13] ALZHEIMERS PRESENILE-DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWNS-SYNDROME IN MIDDLE-AGE FORM AN AGE-RELATED CONTINUUM OF PATHOLOGICAL-CHANGES [J].

MANN, DMA ;

YATES, PO ;

MARCYNIUK, B .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1984, 10 (03) :185-207

[14]

MANN DMA, IN PRESS NEUROSCI LE

[15] BETA-AMYLOID PEPTIDES DESTABILIZE CALCIUM HOMEOSTASIS AND RENDER HUMAN CORTICAL-NEURONS VULNERABLE TO EXCITOTOXICITY [J].

MATTSON, MP ;

CHENG, B ;

DAVIS, D ;

BRYANT, K ;

LIEBERBURG, I ;

RYDEL, RE .

JOURNAL OF NEUROSCIENCE, 1992, 12 (02) :376-389

[16] A MUTATION IN THE AMYLOID PRECURSOR PROTEIN ASSOCIATED WITH HEREDITARY ALZHEIMERS-DISEASE [J].

MURRELL, J ;

FARLOW, M ;

GHETTI, B ;

BENSON, MD .

SCIENCE, 1991, 254 (5028) :97-99

[17]

Pearson R C, 1989, Rev Neurosci, V2, P101, DOI 10.1515/REVNEURO.1989.2.2.101

[18] ANATOMICAL CORRELATES OF THE DISTRIBUTION OF THE PATHOLOGICAL-CHANGES IN THE NEOCORTEX IN ALZHEIMER-DISEASE [J].

PEARSON, RCA ;

ESIRI, MM ;

HIORNS, RW ;

WILCOCK, GK ;

POWELL, TPS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) :4531-4534

[19] THE OCCULT AFTERMATH OF BOXING [J].

ROBERTS, GW ;

ALLSOP, D ;

BRUTON, C .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (05) :373-378

[20] BETA-A4 AMYLOID PROTEIN DEPOSITION IN BRAIN AFTER HEAD TRAUMA [J].

ROBERTS, GW ;

GENTLEMAN, SM ;

LYNCH, A ;

GRAHAM, DI .

LANCET, 1991, 338 (8780) :1422-1423