AN ANATOMICAL CASCADE HYPOTHESIS FOR ALZHEIMERS-DISEASE

被引：73
作者：
HARDY, J
机构：
[1] Dept of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London
来源：
TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 06期
关键词：
D O I：
10.1016/0166-2236(92)90033-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The molecular mechanisms of the cytopathology of Alzheimer's disease are very rapidly being elucidated However, the factors that restrict the effects of this disease to specific neuroanatomical systems are less well understood. In this brief article a possible hypothesis is outlined to explain this apparent specific localization.
引用
收藏
页码：200 / 201
页数：2
相关论文
共 26 条
[1]   INDUCTION OF AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER HEAT-SHOCK IN CULTURED HUMAN LYMPHOBLASTOID-CELLS [J].
ABE, K ;
STGEORGEHYSLOP, PH ;
TANZI, RE ;
KOGURE, K .
NEUROSCIENCE LETTERS, 1991, 125 (02) :169-171
[2]   SELECTIVE INDUCTION OF KUNITZ-TYPE PROTEASE INHIBITOR DOMAIN-CONTAINING AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER PERSISTENT FOCAL ISCHEMIA IN RAT CEREBRAL-CORTEX [J].
ABE, K ;
TANZI, RE ;
KOGURE, K .
NEUROSCIENCE LETTERS, 1991, 125 (02) :172-174
[3]   The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease [J].
Arnold, Steven E. ;
Hyman, Bradley T. ;
Flory, Jill ;
Damasio, Antonio R. ;
Van Hoesen, Gary W. .
CEREBRAL CORTEX, 1991, 1 (01) :103-116
[4]   LOCALIZATION OF AMYLOID BETA-PROTEIN MESSENGER-RNA IN BRAINS FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].
BAHMANYAR, S ;
HIGGINS, GA ;
GOLDGABER, D ;
LEWIS, DA ;
MORRISON, JH ;
WILSON, MC ;
SHANKAR, SK ;
GAJDUSEK, DC .
SCIENCE, 1987, 237 (4810) :77-80
[5]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259
[6]   SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE [J].
GOATE, A ;
CHARTIERHARLIN, MC ;
MULLAN, M ;
BROWN, J ;
CRAWFORD, F ;
FIDANI, L ;
GIUFFRA, L ;
HAYNES, A ;
IRVING, N ;
JAMES, L ;
MANT, R ;
NEWTON, P ;
ROOKE, K ;
ROQUES, P ;
TALBOT, C ;
PERICAKVANCE, M ;
ROSES, A ;
WILLIAMSON, R ;
ROSSOR, M ;
OWEN, M ;
HARDY, J .
NATURE, 1991, 349 (6311) :704-706
[7]   INTERLEUKIN-1 REGULATES SYNTHESIS OF AMYLOID BETA-PROTEIN PRECURSOR MESSENGER-RNA IN HUMAN-ENDOTHELIAL CELLS [J].
GOLDGABER, D ;
HARRIS, HW ;
HLA, T ;
MACIAG, T ;
DONNELLY, RJ ;
JACOBSEN, JS ;
VITEK, MP ;
GAJDUSEK, DC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) :7606-7610
[8]   AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE [J].
HARDY, J ;
ALLSOP, D .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) :383-388
[9]  
HARLIN MCC, 1991, NATURE, V353, P844
[10]   EXPRESSION OF APP IN THE EARLY STAGE OF BRAIN-DAMAGE [J].
KAWARABAYASHI, T ;
SHOJI, M ;
HARIGAYA, Y ;
YAMAGUCHI, H ;
HIRAI, S .
BRAIN RESEARCH, 1991, 563 (1-2) :334-338
123