PRENYLATED PROTEINS - THE STRUCTURE OF THE ISOPRENOID GROUP

被引：168
|
作者：
RILLING, HC
BREUNGER, E
EPSTEIN, WW
CRAIN, PF
机构：
[1] UNIV UTAH,DEPT CHEM,SALT LAKE CITY,UT 84112
[2] UNIV UTAH,DEPT MED CHEM,SALT LAKE CITY,UT 84112
来源：
SCIENCE | 1990年 / 247卷 / 4940期
关键词：
D O I：
10.1126/science.2296720
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The mevalonate-derived portion of a prenylated protein from Chinese hamster ovary cells has been established as diterpenoid (C20). This group is linked to a carboxyl-terminal cysteine as a thioether. It was removed from the protein by hydrazinotysis followed by Raney nickel desulfurization, and the resulting hydrocarbon fraction was analyzed by gas chromatography-mass spectrometry.
引用
收藏
页码：318 / 320
页数：3
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