EARLY MYELIN LESIONS IN EXPERIMENTAL ALLERGIC NEURITIS

被引：25

作者：

ROSEN, JL

BROWN, MJ

HICKEY, WF

ROSTAMI, A

机构：

[1] UNIV PENN,SCH MED,DEPT NEUROL,PHILADELPHIA,PA 19104

[2] UNIV PENN,SCH MED,DIV NEUROPATHOL,PHILADELPHIA,PA 19104

来源：

MUSCLE & NERVE | 1990年 / 13卷 / 07期

关键词：

allergic neuritis; lymphocytes; macrophages; myelin; neuritis demyelination;

D O I：

10.1002/mus.880130712

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined the evolution of demyelination in spinal roots of Lewis rats immunized with whole nerve and complete Freund' adjuvant. Roots were morphologically normal until 11 days after immunization, when we found endoneurial edema and myelin vesiculation in the absence of mononuclear cell contacts. Macrophage‐associated myelin stripping was not detected until day 12. Macrophage infiltrations were extensive by day 14, but lymphocytes were sparse. These observations indicate that in experimental allergic neuritis, myelin injury may occur before macrophage‐mediated demyelination, and provide support for an early role of serum factors in the development of this disorder. Copyright © 1990 John Wiley & Sons, Inc.

引用

收藏

页码：629 / 636

页数：8

相关论文

共 50 条

[31] Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma [J].

Chaudhary, Priya ;

Stowell, Cheri ;

Reynaud, Juan ;

Gardiner, Stuart K. ;

Yang, Hongli ;

Williams, Galen ;

Williams, Imee ;

Marsh-Armstrong, Nicholas ;

Burgoyne, Claude F. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2022, 63 (11)

[32] Early influx of macrophages determines susceptibility to experimental allergic encephalomyelitis in Dark Agouti (DA) rats [J].

Mensah-Brown, Eric P. ;

Shahin, Allen ;

Al Shamisi, Mariam ;

Lukic, Miodrag L. .

JOURNAL OF NEUROIMMUNOLOGY, 2011, 232 (1-2) :68-74

[33] Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis [J].

Lazzarotto, Andrea ;

Hamzaoui, Mariem ;

Tonietto, Matteo ;

Dubessy, Anne-Laure ;

Khalil, Michael ;

Pirpamer, Lukas ;

Ropele, Stefan ;

Enzinger, Christian ;

Battaglini, Marco ;

Stromillo, Maria Laura ;

De Stefano, Nicola ;

Filippi, Massimo ;

Rocca, Maria Assunta ;

Gallo, Paolo ;

Gasperini, Claudio ;

Stankoff, Bruno ;

Bodini, Benedetta .

BRAIN, 2024, 147 (04) :1331-1343

[34] Measuring longitudinal myelin water fraction in new multiple sclerosis lesions [J].

Vargas, Wendy S. ;

Monohan, Elizabeth ;

Pandya, Sneha ;

Raj, Ashish ;

Vartanian, Timothy ;

Nguyen, Thanh D. ;

Rua, Sandra M. Hurtado ;

Gauthier, Susan A. .

NEUROIMAGE-CLINICAL, 2015, 9 :369-375

[35] Effect of fasudil on experimental autoimmune neuritis and its mechanisms of action [J].

Zhao, Yanyin ;

Liu, Bingyou ;

Wang, Yi ;

Xiao, Baoguo .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2020, 53 (01)

[36] Accumulation of Fascin+ cells during experimental autoimmune neuritis [J].

Yang, Zichen ;

Sun, Jian ;

Yang, Xiaofeng ;

Zhang, Zhiyuan ;

Lou, Bangwei ;

Xiong, Jian ;

Schluesener, Hermann J. ;

Zhang, Zhiren .

DIAGNOSTIC PATHOLOGY, 2013, 8

[37] FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves [J].

Zhang, Zhiren ;

Zhang, Zhi-Yuan ;

Fauser, Uwe ;

Schluesener, Hem-Iann J. .

EXPERIMENTAL NEUROLOGY, 2008, 210 (02) :681-690

[38] EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - FREQUENT SAMPLING OF BLOOD ALTERS DISEASE COURSE [J].

TRAUGOTT, U ;

RAINE, CS .

ACTA NEUROPATHOLOGICA, 1979, 48 (03) :171-175

[39] AUY954, a selective S1P1 modulator, prevents experimental autoimmune neuritis [J].

Zhang, Zhi-Yuan ;

Zhang, Zhiren ;

Zug, Caroline ;

Nuesslein-Hildesheim, Barbara ;

Leppert, David ;

Schluesener, Hermann J. .

JOURNAL OF NEUROIMMUNOLOGY, 2009, 216 (1-2) :59-65

[40] Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis [J].

Forge, JK ;

Pedchenko, TV ;

LeVine, SM .

LIFE SCIENCES, 1998, 63 (25) :2271-2284

← 1 2 3 4 5 →