Personalized medicine for gastroenteropancreatic neuroendocrine tumors: a distant dream?

被引：1
作者：
Basuroy, Ron [1 ]
Sarker, Debashis [1 ,2 ]
Quaglia, Alberto [1 ,3 ]
Srirajaskanthan, Rajaventhan [1 ,4 ]
Ramage, John [1 ,5 ]
机构：
[1] Kings Coll Hosp London, ENETS Neuroendocrine Ctr Excellence, Inst Liver Studies, London SE5 9RS, England
[2] Kings Coll London, Dept Res Oncol, Div Canc Studies, London WC2R 2LS, England
[3] Kings Coll Hosp London, Histopathol Dept, Inst Liver Studies, London SE5 9RS, England
[4] Univ Hosp Lewisham, Gastroenterol Dept, London SE13 6LH, England
[5] Hampshire Hosp NHS Trust, Gastroenterol Dept, Basingstoke RG24 9NA, Hants, England
来源：
INTERNATIONAL JOURNAL OF ENDOCRINE ONCOLOGY | 2015年 / 2卷 / 03期
关键词：
biomarkers; cancer; gastroenteropancreatic; heterogeneity; neuroendocrine tumor; personalized medicine; signaling pathways;
D O I：
10.2217/ije.15.9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuroendocrine tumors are heterogeneous cancers that can present with advanced disease. Treatment stratification is often based on limited characterization of tumor behavior from histological grade and imaging assessments. Personalized medicine strategies focus on tailoring therapy through characterization of cancer pathways and the development of biomarkers. This review article explores the current personalized medicine landscape in gastroenteropancreatic neuroendocrine tumors, from tissue and circulating biomarkers development through to tumor heterogeneity and reimbursement issues.
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收藏
页码：201 / 215
页数：15
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