INTERLEUKIN-1 IS RELEASED BY MURINE MACROPHAGES DURING APOPTOSIS INDUCED BY SHIGELLA-FLEXNERI

被引：192

作者：

ZYCHLINSKY, A

FITTING, C

CAVAILLON, JM

SANSONETTI, PJ

机构：

[1] INSERM,U389,UNITE PATHOGENIE MICROBIENNE MOLEC,F-75724 PARIS 15,FRANCE

[2] INST PASTEUR,UNITE IMMUNOALLERGOL,F-75724 PARIS 15,FRANCE

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1994年 / 94卷 / 03期

关键词：

INFLAMMATION; CELL DEATH; ENTEROBACTERIA; COLON; INFECTION;

D O I：

10.1172/JCI117452

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Peritoneal macrophages undergoing apoptosis induced by Shigella flexneri infection release the inflammatory cytokine interleukin 1 (IL-1), but not IL-6 or tumor necrosis factor alpha (TNF alpha). Wild type shigella causes a very fast and significant release of IL-1 from prestimulated peritoneal macrophages, before the cell's integrity is compromised. Both IL-1 alpha and IL-1 beta are released, IL-1 beta in its mature processed form. IL-1 is released from presynthesized cytoplasmic pools. These results demonstrate that bacteria-induced apoptosis of macrophages may play an active role in vivo by releasing IL-1, which in turn mediates an early inflammatory response in epithelial tissues.

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收藏

页码：1328 / 1332

页数：5

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