BELLIDIFOLIN - A POTENT HYPOGLYCEMIC AGENT IN STREPTOZOTOCIN (STZ)-INDUCED DIABETIC RATS FROM SWERTIA-JAPONICA

被引：77
作者：
BASNET, P
KADOTA, S
SHIMIZU, M
NAMBA, T
机构：
[1] TOYAMA MED & PHARMACEUT UNIV, WAKAN YAKU RES INST, TOYAMA 93001, JAPAN
[2] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, TOYAMA 93001, JAPAN
来源：
PLANTA MEDICA | 1994年 / 60卷 / 06期
关键词：
SWERTIA JAPONICA; GENTIANACEAE; XANTHONES; BELLIDIFOLIN; HYPOGLYCEMIC ACTIVITY; STZ-INDUCED DIABETES;
D O I：
10.1055/s-2006-959560
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Hypoglycemic activity-guided fractionation led to the isolation of five known xanthones and two triterpenoids from the ethyl acetate soluble fraction of Swertia japonica and their identification was based on spectroscopic methods. One of the triterpenes, thysanolactone, was first isolated from this plant. Among the xanthones, bellidifolin showed a potent and dose-dependent hypoglycemic activity in STZ-induced diabetic rats both in i.p. and p.o. administration. A comparative hypoglycemic activity of the other three xanthones together with bellidifolin was also studied.
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收藏
页码：507 / 511
页数：5
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