EFFECT OF ASPIRIN ON HEART MITOCHONDRIAL-ENZYMES IN EXPERIMENTAL MYOCARDIAL-INFARCTION IN RATS

被引：0

作者：

MANJULA, TS ^{[1
]}

DEVI, CSS ^{[1
]}

机构：

[1] UNIV MADRAS, DEPT BIOCHEM, GUINDY CAMPUS, MADRAS 600025, TAMIL NADU, INDIA

来源：

BIOCHEMICAL ARCHIVES | 1993年 / 9卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of aspirin on heart mitochondrial enzymes in experimental myocardial infarction induced by isoproterenol was studied in rats. Isoproterenol (20 mg/100 g, sc) was administered twice at a 24 h interval. Aspirin (0.45 mg/100g) was administered orally on alternate days for 3 months. TCA cycle enzymes, NADH dehydrogenase, cytochrome c oxidase, and Na+K+ dependent ATPase were decreased in isoproterenol treated rats. A significant decrease in protease activity was observed with a concomitant increase in the mitochondrial protein level. The mitochondrial lipid peroxide level was increased; thiol content was decreased. Aspirin treatment maintained mitochondrial enzyme activities and thiol content.

引用

页码：101 / 109

页数：9

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