AMINOTRIAZOLE IS A POTENT INHIBITOR OF ALPHA-OXIDATION OF 3-METHYL-SUBSTITUTED FATTY-ACIDS IN RAT-LIVER

被引：30

作者：

CASTEELS, M ^{[1
]}

CROES, K ^{[1
]}

VANVELDHOVEN, PP ^{[1
]}

MANNAERTS, GP ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,B-3000 LOUVAIN,BELGIUM

来源：

BIOCHEMICAL PHARMACOLOGY | 1994年 / 48卷 / 10期

关键词：

AMINOTRIAZOLE; PEROXISOMES; CATALASE; FORMATE; ALPHA-OXIDATION; PHYTANIC ACID;

D O I：

10.1016/0006-2952(94)90596-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The production of CO2 and formate in isolate rat hepatocytes incubated in the presence of 3-methyl[1-C-14]margaric acid was investigated. Production rates of formate were approximately 4-fold lower than those of CO2. Aminotriazole (3-amino-1, 2, 4-triaxole), an irreversible inhibitor of catalase, potently suppressed alpha-oxidation of 3-methylmargaric acid, whereas beta-oxidation of palmitate, 2-methylpalmitate and trihydroxycoprostanic acid and conversion of exogenously added formate to CO2 were not or only slightly affected. This shows that aminotriazole is not only an inhibitor of catalase, but also of alpha-oxidation of 3-methyl-substituted fatty acids.

引用

页码：1973 / 1975

页数：3

共 22 条

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