DETERMINING ZINC COPROPORPHYRIN IN MATERNAL PLASMA - A NEW METHOD FOR DIAGNOSING AMNIOTIC-FLUID EMBOLISM

被引：0

作者：

KANAYAMA, N ^{[1
]}

YAMAZAKI, T ^{[1
]}

NARUSE, H ^{[1
]}

SUMIMOTO, K ^{[1
]}

HORIUCHI, K ^{[1
]}

TERAO, T ^{[1
]}

机构：

[1] HAMAMATSU UNIV SCH MED, DEPT CHEM, HAMAMATSU, SHIZUOKA 43131, JAPAN

来源：

CLINICAL CHEMISTRY | 1992年 / 38卷 / 04期

关键词：

PREGNANCY; FLUOROMETRY; MECONIUM; MATERNAL HEALTH;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We measured the concentration of zinc coproporphyrin I (ZnCP-I), a characteristic component of meconium, in maternal plasma by fluorometry after HPLC. We obtained plasma samples from 89 women: 35 at weeks 10-40 of normal pregnancy, 41 shortly after normal delivery, 4 from patients with amniotic fluid embolism (AFE), and 9 from non-AFE patients with intra- or postpartum shock caused by genital bleeding. The plasma ZnCP-I concentration was 97 (SD 83, range 38-240) nmol/L in the AFE patients, 11 (SD 9.2) nmol/L in the non-AFE patients, 12 (SD 7.9) nmol/L during normal pregnancy, and 26 (SD 1 0) nmol/L shortly after normal delivery. We suggest that measuring ZnCP-I in maternal plasma by fluorometry on HPLC is a rapid, noninvasive, and sensitive method for diagnosing AFE and propose 35 nmol/L as the cutoff value for the ZnCP-I concentration in maternal plasma for the diagnosis of AFE.

引用

页码：526 / 529

页数：4

共 14 条

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