NONRANDOM ASSOCIATION BETWEEN HUNTINGTON DISEASE AND 2 LOCI SEPARATED BY ABOUT 3-MB ON 4P-16.3

被引：25
作者：
ANDREW, S
THEILMANN, J
HEDRICK, A
MAH, D
WEBER, B
HAYDEN, MR
机构：
[1] Department of Medical Genetics, University of British Columbia, Vancouver
来源：
GENOMICS | 1992年 / 13卷 / 02期
关键词：
D O I：
10.1016/0888-7543(92)90246-O
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The gene for Huntington disease (HD) has been localized close to the telomere on the short arm of chromosome 4. However, refined mapping using recombinant HD chromosomes has resulted in conflicting findings and mutually exclusive candidate regions. Previously reported significant nonrandom allelic association between D4S95 and HD provided support for a more proximal location for the defective gene. In this paper, we have analyzed 17 markers, spanning approximately 6 Mb of DNA distal to locus D4S62, for nonrandom association to HD. We confirm the previous findings of nonrandom allelic association between D4S95 and HD. In addition, we provide new data showing significant nonrandom association between HD and 3 markers at D4S133 and D4S228, which are approximately 3 Mb telomeric to D4S95. © 1992.
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页码：301 / 311
页数：11
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