PIP92 - A SHORT-LIVED, GROWTH FACTOR-INDUCIBLE PROTEIN IN BALB/C 3T3 AND PC12 CELLS

被引：34

作者：

CHARLES, CH ^{[1
]}

SIMSKE, JS ^{[1
]}

OBRIEN, TP ^{[1
]}

LAU, LF ^{[1
]}

机构：

[1] UNIV ILLINOIS, COLL MED, DEPT GENET, 808 S WOOD ST, CHICAGO, IL 60612 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 12期

关键词：

D O I：

10.1128/MCB.10.12.6769

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

pip92 is a cellular immediate-early gene inducible by serum growth factors in fibroblasts. It is also induced in the rat pheochromocytoma cell line PC12 by agents that cause proliferation, neuronal differentiation, and membrane depolarization. We show that the pip92-encoded polypeptide is a proline-rich protein of 221 amino acids, has an extremely short half-life, and is localized in the cytoplasm. We hypothesize that Pip92 plays a role in mediating the cellular responses to a variety of extracellular signals.

引用

页码：6769 / 6774

页数：6

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