Melatonin Effects on EEG Activity During Sleep Onset in Mild-to-Moderate Alzheimer's Disease: A Pilot Study

被引:22
作者
Alejandro Cruz-Aguilar, Manuel [1 ,2 ]
Ramirez-Salado, Ignacio [2 ]
Angel Guevara, Miguel [1 ]
Hernandez-Gonzalez, Marisela [3 ]
Benitez-King, Gloria [4 ]
机构
[1] Univ Guadalajara, Inst Neurociencias, Lab Correlac Electroencefalograf & Conducta, CUCBA, Guadalajara, Jalisco, Mexico
[2] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Direcc Invest Neurociencias, Lab Cronobiol & Sueno, Cdmx, Mexico
[3] Univ Guadalajara, Inst Neurociencias, CUCBA, Lab Neurofisiol Conducta Reprod, Guadalajara, Jalisco, Mexico
[4] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Subdirecc Invest Clin, Lab Neurofarmacol, Cdmx, Mexico
关键词
Alzheimer's disease; EEG correlation; electroencephalography; melatonin; relative power; sleep onset; suprachi-asmatic nucleus;
D O I
10.3233/ADR-170019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is evidence demonstrating that 5-mg of fast-release melatonin significantly reduces nocturnal sleep onset in patients with mild-to-moderate Alzheimer's disease (AD). However, the physiological mechanism that could promote sleep installation by melatonin in patients with AD is still poorly understood. The present pilot study was designed to analyze the effects of melatonin on cortical activity during the sleep onset period (SOP) in eight mild-to-moderate AD patients treated with 5-mg of fast-release melatonin. Electroencephalographic recordings were obtained from C3-A1, C4-A2, F7-T3, F8-T4, F3-F4, and 01-02. The relative power (RP), interhemispheric, intrahemispheric, and fronto-posterior correlations of six electroencephalographic bands were calculated and compared between two conditions: placebo and melatonin. Results show that at F7-T3, F3-F4, and C3-A1, melatonin induced an increase of the RP of the delta band. Likewise, in F7-T3, melatonin induced a decrease of the RP in the alphal band Similarly, results show a lower interhemispheric correlation between the F7-T3 and F8-T4 derivations in the alphal band compared to the placebo condition. We conclude that the short sleep onset related to melatonin intake in AD patients was associated with a lower RP of the alphal, a higher RP of the delta band (mainly in the left hemisphere) and a decreased interhemispheric EEG coupling in the alphal band. The possible role of the GABAergic neurotransmission as well as of the cascade of neurochemical events that melatonin triggers on sleep onset are discussed.
引用
收藏
页码:55 / 65
页数:11
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