(Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one

被引：1

作者：

Mohan, Billava Jayappa ^{[1
]}

Sarojini, Balladka Kunhanna ^{[2
]}

Narayana, Badiadka ^{[3
]}

Priya, Enumadishetty Srinivasulu Sindhu ^{[4
,5
]}

机构：

[1] PA Coll Engn, Dept Chem, Mangaluru 574153, Karnataka, India

[2] Mangalore Univ, Dept Ind Chem, Mangaluru 574199, Karnataka, India

[3] Mangalore Univ, Dept Studies Chem, Mangaluru 574199, Karnataka, India

[4] Yenepoya Deemed Univ, Dept Pharmacol, Mangaluru 574153, Karnataka, India

[5] Yenepoya Deemed Univ, Yenepoya Res Ctr, Mangaluru 574153, Karnataka, India

来源：

MOLBANK | 2018年 / 02期

关键词：

pyrazol-5(4H)-one; hydrazine hydrate; anti-inflammatory; antiproliferative; antibacterial activity;

D O I：

10.3390/M989

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound (Z)-4-[2-(3,4-difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one 4 was synthesized by the reaction of ethyl 2-[2-(3,4-difluorophenyl)hydrazono]-3-oxobutanoate 3 with hydrazine hydrate. The diazotization of 3,4-difluoroaniline, followed by the treatment with ethyl acetoacetate, afforded intermediate 3. The synthesized compound 4 was characterized by FTIR, H-1-NMR, C-13-NMR and LCMS, and it showed synergistic anti-inflammatory, antiproliferative and antibacterial activities.

引用

页数：9

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