Zebrafish phenomics: behavioral screens and phenotyping of mutagenized fish

被引：31

作者：

Gerlai, Robert ^{[1
]}

机构：

[1] Univ Toronto, Dept Psychol, Mississauga, ON, Canada

来源：

CURRENT OPINION IN BEHAVIORAL SCIENCES | 2015年 / 2卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.cobeha.2014.07.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The zebrafish is small, easy to keep, and breeds in large quantities, features that make it attractive for high throughput mutagenesis screening. It is translationally relevant due to evolutionary conservation of several of its characteristics, but particularly because of the high nucleotide sequence homology between zebrafish and human genes. Behavioral genetics also noticed this species. Although still very small, the number of behavioral paradigms designed for zebrafish is exponentially increasing and the marriage between behavioral sciences and genetics is becoming a reality for zebrafish. This paper reviews the latest developments of this rapidly expanding field with illustrative examples on novel behavioral paradigms drawn from the work of the author's laboratory along with a short discussion on modern forward genetic methods.

引用

页码：21 / 27

页数：7

共 34 条

[21] ENU mutagenesis in zebrafish - from genes to complex diseases [J].