This investigation is concerned with the peristaltic transport of Nanofluid in an inclined annulus tube. Transport equations involve the combined effects of Brownian motion and thermophoretic diffusion of nanoparticles. Mathematical modeling is carried out by utilizing long wavelength and low Reynolds number assumptions. Attention has been focused on the behaviors of Brownian motion parameter (Nb), thermophoresis parameter (Nt) and inclination of the annulus. The result indicates an appreciable increase in the temperature and nanoparticles concentration with the increase in the strength of Brownian motion effects, and the inclination angle increases the pressure rise.