STARFISH SAPONINS .45. NOVEL SULFATED STEROIDAL GLYCOSIDES FROM THE STARFISH ASTROPECTEN-SCOPARIUS

Five sulfated steroidal glycosides have been isolated from the H2O extracts of the whole bodies of the starfish Astropecten scoparius. One of them has been identified with indicoside B [1], a sulfated steroidal xylofuranoside previously isolated from Astropecten indicus, and the remaining four are new compounds. Three of them, scopariosides A [2], B [3], and C [4] have the same (24S)-5α-cholestane-3β,6α,8,15β,24-pentaol aglycone as indicoside B but differ in the sugar moieties. The aglycone is also present in the H2O extracts as 24-O-sulfate derivative. The fourth new glycoside, scoparioside D, has been characterized as (24R)-24-O-β-xylopyranosyl-5α-cholest-22E-ene-3β,6α,8,15-tetraol 15-sulfate [5]. These glycosides are accompanied by four known polyhydroxysteroids 7-10 and one known asterosaponin, the hexaglycoside marthasteroside A1. © 1990, American Chemical Society. All rights reserved.