INACTIVATION OF CARBOXYPEPTIDASE-A BY 2-BENZYL-3,4-EPITHIOBUTANOIC ACID

被引：18

作者：

KIM, DH ^{[1
]}

CHUNG, SJ ^{[1
]}

机构：

[1] POHANG UNIV SCI & TECHNOL,DEPT CHEM,POHANG 790784,SOUTH KOREA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00271-T

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Benzyl-3,4-epithiobutanoic acid was designed and synthesized as a pseudomechanism-based inactivator for carboxypeptidase A. Designing rationale, synthesis of racemic 2-benzyl-3,4-epithiobutanoic acid having (2S,3S)- and (2R,3R)-configurations, and inhibitory kinetic parameters and their implications are reported.

引用

页码：1667 / 1672

页数：6

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