Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study

被引：12

作者：

Chornokur, Ganna ^{[1
,2
]}

Amankwah, Ernest K. ^{[1
]}

Davis, Stacy N. ^{[3
]}

Phelan, Catherine M. ^{[1
,2
]}

Park, Jong Y. ^{[1
]}

Pow-Sang, Julio ^{[4
]}

Kumar, Nagi B. ^{[1
,2
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA

[2] Ctr Equal Hlth, Tampa, FL 33612 USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Hlth Outcomes & Behav, Tampa, FL 33612 USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Genitourinary Oncol, Tampa, FL 33612 USA

来源：

PROSTATE CANCER | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/384594

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) andWhite (EAM) men. We further explored if these associations varied by the body mass index (BMI) and height. Methods. Age-matched DNA samples from 259 AAM and 269 EAM were genotyped for 10 candidate SNPs in 7 genes using the TaqMan allelic differentiation analysis. The dominant, recessive, and additive age-adjusted unconditional logistic regression models were fitted. Results. Three SNPs showed statistically significant associations with PCa risk: in AAM, HNF1B rs7501939 (OR = 2.42, P = 0.0046) and rs4430796 (OR = 0.57, P = 0.0383); in EAM, CTBP2 rs4962416 (OR = 1.52, P = 0.0384). In addition, high BMI in AAM (OR = 1.06, P = 0.022) and height in EAM (OR = 0.92, P = 0.0434) showed significant associations. Interestingly, HNF1B rs7501939 was associated with PCa exclusively in obese AAM (OR = 2.14, P = 0.0103). Conclusion. Our results suggest that variation in the HNF1B may influence PCa risk in obese AAM.

引用

页数：7

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