STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATES WITH BIFUNCTIONAL REAGENTS .3. FURTHER-STUDIES ON TRANSESTERIFICATION OF NUCLEOSIDE H-PHOSPHONATE DIESTERS WITH AMINO-ALCOHOLS

被引：5

作者：

SOBKOWSKI, M

STAWINSKI, J

SOBKOWSKA, A

KRASZEWSKI, A

机构：

[1] POLISH ACAD SCI,INST BIOORGAN CHEM,PL-60704 POZNAN,POLAND

[2] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1080/15257779508012484

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactions of 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 2-cyanoethyl phosphonate with alcohols, amines and amino alcohols in pyridine are described. Transesterification was found to be faster than beta-elimination of 2-cyanoethyl group.

引用

页码：839 / 842

页数：4

共 33 条

[1] STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATES WITH BIFUNCTIONAL REAGENTS .2. STABILITY OF NUCLEOSIDE H-PHOSPHONATE DIESTERS IN THE PRESENCE OF AMINO-ALCOHOLS
SOBKOWSKI, M
STAWINSKI, J
SOBKOWSKA, A
KRASZEWSKI, A
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1994, (13): : 1803 - 1808
[2] STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATES WITH BIFUNCTIONAL REAGENTS .1. REACTION WITH AMINO-ALCOHOLS
KRASZEWSKI, A
SOBKOWSKI, M
STAWINSKI, J
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (14): : 1699 - 1704
[3] STUDIES ON REACTIONS OF NUCLEOSIDE H-PHOSPHONATE DIESTERS WITH BIFUNCTIONAL REAGENTS .4. CHEMOSELECTIVITY DURING OXIDATIVE COUPLING OF NUCLEOSIDE H-PHOSPHONATE DIESTERS WITH AMINO-ALCOHOLS CONTROLLED BY PROTONATION OF THE AMINO FUNCTION
SOBKOWSKI, M
STAWINSKI, J
KRASZEWSKI, A
TETRAHEDRON LETTERS, 1995, 36 (13) : 2295 - 2298
[4] Exploring reactions of nucleoside H-phosphonates with bifunctional reagents
Stawinski, J
Kraszewski, A
Sobkowski, M
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1996, 109 (1-4) : 261 - 264
[5] NUCLEOSIDE H-PHOSPHONATES .13. STUDIES ON 3H-1,2-BENZODITHIOL-3-ONE DERIVATIVES AS SULFURIZING REAGENTS FOR H-PHOSPHONATE AND H-PHOSPHONOTHIOATE DIESTERS
STAWINSKI, J
THELIN, M
JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (17): : 5169 - 5175
[6] Aryl H-phosphonates .4. A new method for internucleotide bond formation based on transesterification of aryl nucleoside H-phosphonate diesters
Cieslak, J
Sobkowski, M
Kraszewski, A
Stawinski, J
TETRAHEDRON LETTERS, 1996, 37 (26) : 4561 - 4564
[7] Studies on reactions of nucleoside H-phosphonates with bifunctional reagents.: Part VI.: Reaction with diols
Sobkowski, M
Wenska, M
Kraszewski, A
Stawinski, J
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2000, 19 (10-12): : 1487 - 1503
[8] Use of ammonium aryl H-phosphonates in the preparation of nucleoside H-phosphonate building blocks
Ozola, V
Reese, CB
Song, QL
TETRAHEDRON LETTERS, 1996, 37 (47) : 8621 - 8624
[9] Aryl H-phosphonates .5. A simple method for the synthesis of aminoalkyl H-phosphonate monoesters via transesterification of diphenyl H-phosphonate with amino alcohols
Sobkowski, M
Stawinski, J
Kraszewski, A
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1996, 61 : S238 - S241
[10] Nucleoside H-phosphonates .16. P-31 NMR studies on the transformation of nucleoside H-phosphonate monoesters into a monofunctional tervalent intermediate, nucleoside acyl silyl phosphite
Zain, R
Stawinski, J
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1996, (05): : 795 - 799

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