HIGH-FREQUENCY OF MUTAGEN-INDUCED CHROMATID EXCHANGES AT INTERSTITIAL TELOMERE-LIKE DNA-SEQUENCE BLOCKS OF CHINESE-HAMSTER CELLS

被引：39

作者：

FERNANDEZ, JL

GOSALVEZ, J

GOYANES, V

机构：

[1] HOSP TERESA HERRERA,UNIDAD GENET,E-15006 LA CORUNA,SPAIN

[2] UNIV AUTONOMA MADRID,DEPT BIOL,UNIDAD GENET,E-28049 MADRID,SPAIN

来源：

CHROMOSOME RESEARCH | 1995年 / 3卷 / 05期

关键词：

CHROMOSOME ABERRATIONS; FISH; IONIZING RADIATION; MITOMYCIN C; TELOMERE SEQUENCES; TENIPOSIDE (VM-26);

D O I：

10.1007/BF00713065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interstitial telomere-like DNA sequence arrays of Chinese hamster Don cells were delineated by fluorescence in situ hybridization in quadriradial and triradial chromosome configurations induced by X-rays, mitomycin C and teniposide (VM-26). Around 40% of the scored exchanges involved a telomeric-like block of sequences at a rearrangement site. This frequency was independent of the DNA-damaging agent, and the result suggests a general recombinogenic capacity of interstitial telomere-like DNA sequence repeats that, at least in the case of the agents employed, seems not to be related to the initial mechanism of DNA damage.

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页码：281 / 284

页数：4

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