ENDOCRINE AND PARACRINE CONTROL OF OOCYTE DEVELOPMENT

被引：45
作者：
DANFORTH, DR
机构：
[1] Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1995年 / 172卷 / 02期
关键词：
GONADOTROPINS; OOCYTES; PARACRINE FACTORS; GROWTH FACTORS;
D O I：
10.1016/0002-9378(95)90148-5
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The effects of gonadotropins on oocyte development are mediated through a variety of mechanisms. including production by granulosa cells of growth factors, cytokines, inhibins, activins, and steroids. Specific receptors for steroids, growth factors, and cytokines have been demonstrated on oocytes of several species. Gonadotropin modulation of follicular concentrations of these paracrine factors may ultimately be responsible for the precise regulation of oocyte function. As gonadotropin-releasing hormone antagonists and recombinant gonadotropins become available, the clinical use of more precise control of the endocrine, paracrine, and autocrine regulation of follicle growth and oocyte development can be more thoroughly investigated.
引用
收藏
页码：747 / 752
页数：6
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