DECLINE IN CD4+ CELL NUMBERS IN CATS WITH NATURALLY ACQUIRED FELINE IMMUNODEFICIENCY VIRUS-INFECTION

被引：94

作者：

HOFFMANNFEZER, G

THUM, J

ACKLEY, C

HERBOLD, M

MYSLIWIETZ, J

THEFELD, S

HARTMANN, K

KRAFT, W

机构：

[1] GESELL STRAHLEN & UMWELTFORSCH MBH,MEDIS INST,W-8042 NEUHERBERG,GERMANY

[2] UNIV ALABAMA,SCH MED,BIRMINGHAM,AL 35294

[3] UNIV MUNICH,MED TIERKLIN,W-8000 MUNICH 2,GERMANY

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 03期

关键词：

D O I：

10.1128/JVI.66.3.1484-1488.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4+-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decreased and CD8+ values were increased. The CD4+/CD8+ ratio was reduced to 1.6, compared with 3.3 in 33 FIV-seronegative control cats. Variance analysis of data showed a significant influence of FIV seropositivity, sex, and spaying of female cats on CD4+ values. CD8+ values were significantly influenced by FIV seropositivity, age, and breed. These findings indicate a similarity between FIV and human immunodeficiency virus infections, as far as alterations of T-cell subsets are concerned.

引用

页码：1484 / 1488

页数：5

共 15 条

[11] FELINE IMMUNODEFICIENCY VIRUS-INFECTION [J].