DECLINE IN CD4+ CELL NUMBERS IN CATS WITH NATURALLY ACQUIRED FELINE IMMUNODEFICIENCY VIRUS-INFECTION

被引：94
作者：
HOFFMANNFEZER, G
THUM, J
ACKLEY, C
HERBOLD, M
MYSLIWIETZ, J
THEFELD, S
HARTMANN, K
KRAFT, W
机构：
[1] GESELL STRAHLEN & UMWELTFORSCH MBH,MEDIS INST,W-8042 NEUHERBERG,GERMANY
[2] UNIV ALABAMA,SCH MED,BIRMINGHAM,AL 35294
[3] UNIV MUNICH,MED TIERKLIN,W-8000 MUNICH 2,GERMANY
来源：
JOURNAL OF VIROLOGY | 1992年 / 66卷 / 03期
关键词：
D O I：
10.1128/JVI.66.3.1484-1488.1992
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4+-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decreased and CD8+ values were increased. The CD4+/CD8+ ratio was reduced to 1.6, compared with 3.3 in 33 FIV-seronegative control cats. Variance analysis of data showed a significant influence of FIV seropositivity, sex, and spaying of female cats on CD4+ values. CD8+ values were significantly influenced by FIV seropositivity, age, and breed. These findings indicate a similarity between FIV and human immunodeficiency virus infections, as far as alterations of T-cell subsets are concerned.
引用
收藏
页码：1484 / 1488
页数：5
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