THE INVOLVEMENT OF IRON AND LIPID-PEROXIDATION IN THE PATHOGENESIS OF HCB INDUCED PORPHYRIA

被引：21

作者：

ALLEMAN, MA

KOSTER, JF

WILSON, JHP

EDIXHOVENBOSDIJK, A

SLEE, RG

KROOS, MJ

VANEIJK, HG

机构：

[1] ERASMUS UNIV, FAC MED, DEPT INTERNAL MED 2, DR MOLEWATERPLEIN 40, 3015 GD ROTTERDAM, NETHERLANDS

[2] ERASMUS UNIV, FAC MED, DEPT BIOCHEM 1, 3015 GD ROTTERDAM, NETHERLANDS

[3] ERASMUS UNIV, FAC MED, DEPT CHEM PATHOL, 3015 GD ROTTERDAM, NETHERLANDS

[4] ERASMUS UNIV HOSP, 3015 GD ROTTERDAM, NETHERLANDS

来源：

BIOCHEMICAL PHARMACOLOGY | 1985年 / 34卷 / 02期

关键词：

D O I：

10.1016/0006-2952(85)90118-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hexachlorobenzene (HCB) induces a porphyria characterized by a diminished activity of the enzyme uroporphyrinogen decarboxylase (URO-D), presumably due to inactivation by reactive metabolites of HCB. The effect of Fe on HcB porphyria was studied in female rats, to determine whether the Fe-dependent process of lipid peroxidation was involved in the pathogenesis of porphyria. Malondialdehyde formation was increased in rat liver tissue of porphyric rats and high MW proteins due to cross-linking are formed. The induction of porphyria by HcB was dependent on the presence of Fe. Lipid peroxidation was apparently involved in the toxicity of HCB and the aggravating effects of iron on HCB were mediated by lipid peroxidation.

引用

页码：161 / 166

页数：6

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