Development of plumbagin-loaded phospholipid-Tween (R) 80 mixed micelles: formulation, optimization, effect on breast cancer cells and human blood/serum compatibility testing

被引：1
作者：
Bothiraja, Chellampillai [1 ]
Kapare, Harshad S. [1 ]
Pawar, Atmaram P. [1 ]
Shaikh, Karimunnisa S. [2 ]
机构：
[1] Bharati Vidyapeeth Univ, Poona Coll Pharm, Dept Pharmaceut, Pune 411038, Maharashtra, India
[2] Univ Pune, Modern Coll Pharm, Dept Pharmaceut, Pune 411044, Maharashtra, India
来源：
THERAPEUTIC DELIVERY | 2013年 / 4卷 / 10期
关键词：
D O I：
10.4155/TDE.13.92
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: Phospholipid and Tween (R) 80 mixed micelles were investigated as injectable nanocarriers for the natural anticancer compound, plumbagin (PBG), with the aim to improve anticancer efficiency. PBG-loaded mixed micelles were fabricated by self-assembly; composition being optimized using 3(2) factorial design. Results & discussion: Optimized mixed micelles were spherical and 46 nm in size. Zeta potential, drug loading and encapsulation efficiency were 5.04 mV, 91.21 and 98.38% respectively. Micelles demonstrated sustained release of PBG. Micelles caused a 2.1-fold enhancement in vitro antitumor activity of PBG towards MCF-7 cells. Micelles proved safe for intravenous injection as PBG was stable at high pH; micelle size and encapsulation efficiency were retained upon dilution. Conclusion: Developed mixed micelles proved potential nanocarriers for PBG in cancer chemotherapy.
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收藏
页码：1247 / 1259
页数：13
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