How the ubiquitin proteasome system regulates the regulators of transcription

被引：9

作者：

Ee, Gary ^{[1
]}

Lehming, Norbert ^{[1
]}

机构：

[1] Natl Univ Singapore, Yong Lao Lin Sch Med, Dept Microbiol, Singapore, Singapore

来源：

TRANSCRIPTION-AUSTIN | 2012年 / 3卷 / 05期

关键词：

Gal4; transcription; ubiquitin; conditional protein degradation;

D O I：

10.4161/trns.21249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ubiquitin proteasome system plays an important role in transcription. Monoubiquitination of activators is believed to aid their function, while the 26S proteasomal degradation of repressors is believed to restrict their function. What remains controversial is the question of whether the degradation of activators aids or restricts their function.

引用

页码：235 / 239

页数：5

共 50 条

[21] Stressing the ubiquitin-proteasome system
Dantuma, Nico P.
Lindsten, Kristina
CARDIOVASCULAR RESEARCH, 2010, 85 (02) : 263 - 271
[22] Increased transcription of ubiquitin-proteasome system components: molecular responses associated with muscle atrophy
Price, SR
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2003, 35 (05) : 617 - 628
[23] Transcription alterations of members of the ubiquitin–proteasome network in prostate carcinoma
O J C Hellwinkel
L E Asong
J-P Rogmann
H Sültmann
C Wagner
T Schlomm
C Eichelberg
Prostate Cancer and Prostatic Diseases, 2011, 14 : 38 - 45
[24] The Ubiquitin-Proteasome Pathway Regulates Claudin 5 Degradation
Mandel, Ilana
Paperna, Tamar
Volkowich, Anat
Merhav, Maayan
Glass-Marmor, Lea
Miller, Ariel
JOURNAL OF CELLULAR BIOCHEMISTRY, 2012, 113 (07) : 2415 - 2423
[25] REGγ regulates ERα degradation via ubiquitin-proteasome pathway in breast cancer
Chai, Fan
Liang, Yan
Bi, Jiong
Chen, Li
Zhang, Fan
Cui, Youhong
Jiang, Jun
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 456 (01) : 534 - 540
[26] Hepatocellular carcinoma and the ubiquitin-proteasome system
Dawson, Simon P.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2008, 1782 (12): : 775 - 784
[27] The role of ubiquitin-proteasome system in ageing
Peter Loew
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2011, 172 (01) : 39 - 43
[28] Therapeutic strategies within the ubiquitin proteasome system
A G Eldridge
T O'Brien
Cell Death & Differentiation, 2010, 17 : 4 - 13
[29] The role of the ubiquitin–proteasome system in kidney diseases
Hirotaka Fukasawa
Clinical and Experimental Nephrology, 2012, 16 : 507 - 517
[30] The regulation of mitochondrial homeostasis by the ubiquitin proteasome system
Alsayyah, Cynthia
Ozturk, Oznur
Cavellini, Laetitia
Belgareh-Touze, Naima
Cohen, Mickael M.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2020, 1861 (12):

← 1 2 3 4 5 →