How the ubiquitin proteasome system regulates the regulators of transcription

被引：9

作者：

Ee, Gary ^{[1
]}

Lehming, Norbert ^{[1
]}

机构：

[1] Natl Univ Singapore, Yong Lao Lin Sch Med, Dept Microbiol, Singapore, Singapore

来源：

TRANSCRIPTION-AUSTIN | 2012年 / 3卷 / 05期

关键词：

Gal4; transcription; ubiquitin; conditional protein degradation;

D O I：

10.4161/trns.21249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ubiquitin proteasome system plays an important role in transcription. Monoubiquitination of activators is believed to aid their function, while the 26S proteasomal degradation of repressors is believed to restrict their function. What remains controversial is the question of whether the degradation of activators aids or restricts their function.

引用

页码：235 / 239

页数：5

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