ANTIARRHYTHMIC PROPERTIES OF DIMEBON

被引：3
|
作者：
GALENKOYAROSHEVSKII, PA [1 ]
CHEKANOVA, OA [1 ]
SKIBITSKII, VV [1 ]
BARTASHEVICH, VV [1 ]
KHANKOEVA, AI [1 ]
POLYASHOVA, TI [1 ]
机构：
[1] KUBAN MED INST,DEPT PHARMACOL,KRASNODAR,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 04期
关键词：
DIMEBON; ANTIHISTAMINES; ANTIARRHYTHMICS;
D O I：
10.1007/BF02445893
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The H-1-receptor blocker Dimebon is shown to exhibit pronounced antiarrhythmic properties. Its activity and therapeutic action range (toxic/therapeutic ratio) exceed those of quinidine, ethmosine, isoptin, and bonnecor in several animal models of cardiac arrhythmia. The mechanism of its antiarrhythmic action is probably associated with blockade of sodium and particularly calcium channels, prolongation of the effective refractory period, and slowing of impulse traffic in the conduction system of the heart. Dimebon may be recommended for submission to clinical trials as an antiarrhythmic agent.
引用
收藏
页码：362 / 364
页数：3
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