HALOFANTRINE PHARMACOKINETICS IN KENYAN CHILDREN WITH NON-SEVERE AND SEVERE MALARIA

被引:13
作者
WATKINS, WM
WINSTANLEY, PA
MBERU, EK
KOKWARO, G
MURPHY, SA
NEWTON, CJ
MWANGI, I
FORSTER, D
MARSH, K
机构
[1] KENYA GOVT MED RES CTR,CRC,KILIFI RES UNIT,KILIFI,KENYA
[2] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL,MERSEYSIDE,ENGLAND
[3] UNIV NAIROBI,DEPT PHARM,NAIROBI,KENYA
[4] WELLCOME TRUST RES LABS,NAIROBI,KENYA
[5] UNIV OXFORD,NUFFIELD DEPT CLIN MED,OXFORD,ENGLAND
[6] UNIV OXFORD,DEPT PAEDIAT,OXFORD,ENGLAND
基金
英国惠康基金;
关键词
FALCIPARUM MALARIA; HALOFANTRINE; TREATMENT; PHARMACOKINETICS; PARASITE CHEMOSENSITIVITY;
D O I
10.1111/j.1365-2125.1995.tb04450.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 Kenyan children with uncomplicated malaria given oral halofantrine (HF; nonmicronised suspension; 8 mg base kg(-1) body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm). 2 Eight Kenyan children with severe (prostrate) falciparum malaria who were receiving intravenous quinine, were given the same HF regimen by nasogastric tube. One patient had undetectable HF and two had undetectable HFm at all times after drug administration. 3 The mean AUC(0,24 h) of HF in prostrate children was half (7.54 compared with 13.10 mu g ml(-1) h) (P = 0.06), and that for HFm one-third (0.84 compared with 2.51 mu g ml(-1) h) (P < 0.05) of the value in children with uncomplicated malaria. 4 Oral HF may be appropriate for some cases of uncomplicated falciparum malaria in Africa, but in patients with severe malaria, the bioavailability of HF and HFm may be inadequate.
引用
收藏
页码:283 / 287
页数:5
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