ENHANCEMENT OF THE IMMUNE-RESPONSE BY INTRADERMAL VACCINATION IN CATTLE WITH ENTEROTOXIGENIC ESCHERICHIA-COLI (ETEC) VACCINE WITHOUT ADJUVANT

被引：4

作者：

ITZCHAK, S ^{[1
]}

JACOB, B ^{[1
]}

AVRAHAM, R ^{[1
]}

BENAMI, P ^{[1
]}

机构：

[1] KIMRON VET INST, MINIST AGR, IMMUNOL LAB, IL-50250 BET DAGAN, ISRAEL

来源：

VACCINE | 1992年 / 10卷 / 04期

关键词：

INTRADERMAL; SUBCUTANEOUS; INTRAMUSCULAR; ESCHERICHIA-COLI; CATTLE;

D O I：

10.1016/0264-410X(92)90155-D

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A comparison was made of the efficiency of intradermal and subcutaneous routes of vaccination in immunizing cattle with a killed vaccine of Escherichia coli K99 +. In this study 135 heifers aged 8-18 months were included. The effect of the number of intradermal injection sites was examined, as well as the optimal time interval between the initial and booster intradermal vaccination. The intradermal route was found to be significantly superior to the subcutaneous route. The optimal time for intradermal booster was almost-equal-to 2 weeks. Increasing the number of intradermal injection sites up to 50 (using the same amount of antigen) did not result in an enhancement of the antibody level.

引用

页码：217 / 220

页数：4

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