THE INVOLVEMENT OF L-TYPE CALCIUM CHANNELS IN HETEROSYNAPTIC LONG-TERM DEPRESSION IN THE HIPPOCAMPUS

被引：92
作者：
WICKENS, JR
ABRAHAM, WC
机构：
[1] UNIV OTAGO,DEPT PSYCHOL,POB 56,DUNEDIN,NEW ZEALAND
[2] UNIV OTAGO,DEPT ANAT,DUNEDIN,NEW ZEALAND
[3] UNIV OTAGO,NEUROSCI RES CTR,DUNEDIN,NEW ZEALAND
来源：
NEUROSCIENCE LETTERS | 1991年 / 130卷 / 01期
基金：
英国医学研究理事会;
关键词：
LONG-TERM DEPRESSION; HIPPOCAMPUS; CALCIUM; L-CHANNEL; DIHYDROPYRIDINE;
D O I：
10.1016/0304-3940(91)90244-N
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The involvement of L-type calcium channels in heterosynaptic long-term depression (LTD) of the stratum radiatum input to area CA1 was studied in rat hippocampal slices. LTD of the radiatum field excitatory postsynaptic potential (EPSP) and population spike, produced by tetanization of the alveus in the presence of picrotoxin, was blocked by the calcium antagonist nimodipine and by a monoclonal antibody to the L-type calcium channel. LTD was produced in the absence of picrotoxin when the L-type calcium channel agonist, BAY-K8644, was applied. This effect was also blocked by nimodipine. These results indicate that L-type calcium channels are involved in heterosynaptic long-term depression.
引用
收藏
页码：128 / 132
页数：5
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