A FLUOROQUINOLONE (DR-3355) PROTECTS HUMAN LYMPHOCYTE CELL-LINES FROM HIV-1-INDUCED CYTOTOXICITY

被引：10

作者：

NOZAKIRENARD, J

IINO, T

SATO, Y

MARUMOTO, Y

OHTA, G

FURUSAWA, M

机构：

[1] DAIICHI PHARMACEUT CO LTD,RES INST,MOLEC BIOL RES LAB,16-13 KITAKASAI 1 CHOME,EDOGAWA KU,TOKYO 134,JAPAN

[2] TOKYO MED COLL,DEPT MICROBIOL,TOKYO 160,JAPAN

来源：

AIDS | 1990年 / 4卷 / 12期

关键词：

FLUOROQUINOLONE; DR-3355; ANTI-HIV-1; ACTIVITY; CD4; ANTIGEN;

D O I：

10.1097/00002030-199012000-00018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 infection of human CD4+ lymphocyte cell lines results in cell death. Treatment, but not pretreatment, of infected cells, with a fluoroquinolone antibiotic, DR-3355, protects a significant subfraction of cells from HIV-1-mediated cytolysis. All surviving cells have lost expression of the CD4 antigen, but do (MT-4) or do not (CEM) express viral antigens and produce infective virus. The rescued CEM and MT-4 cells are phenotypically stable and do not require continuous exposure to the drug for survival.

引用

页码：1283 / 1286

页数：4

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