SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 1-SUBSTITUTED 3-PYRROLIDINYLUREAS

被引：8

作者：

HELSLEY, GC

FRANKO, BV

WELSTEAD, WJ

LUNSFORD, CD

机构：

[1] Research Laboratories, A. H. Robins company, Inc., Richmond, Virginia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 05期

关键词：

D O I：

10.1021/jm00311a027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-substiuted 3-pyrrolidinylureas was synthesized and evaluated for pharmacologic activity. Some of the activities observed were CNS depressant, antiarrhythmic, local anesthetic, and hypoglycemie. © 1968, American Chemical Society. All rights reserved.

引用

收藏

页码：1034 / &

相关论文

共 8 条

[1] NEUROPHARMACOLOGICAL INVESTIGATION OF N-BENZYLSULFAMIDES [J].

AEBERLI, P ;

GOGERTY, J ;

HOULIHAN, WJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (04) :636-&

[2] The preparation of ureas [J].

Buck, JS ;

Ferry, CW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1936, 58 :854-854

[3] DERIVATIVES OF 3-PYRROLIDINOLS .3. THE CHEMISTRY, PHARMACOLOGY, AND TOXICOLOGY OF SOME N-SUBSTITUTED-3-PYRROLIDYL ALPHA-SUBSTITUTED PHENYLACETATES [J].

FRANKO, BV ;

LUNSFORD, CD .

JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1960, 2 (05) :523-540

[4]

HAACK E, 1955, Patent No. 9688

[5]

HELSLEY GC, 1967, Patent No. 3316276

[6] A NEW GROUP OF ANTIFIBRILLANTS . N-(OMEGA-AMINOALKYL)PHTHALIMIDES [J].

HIDEG, K ;

HANKOVSZ.HO .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (02) :257-&

[7] AMINOALKYLINDOLES WITH CENTRAL NERVOUS SYSTEM ACTIVITY [J].

WELSTEAD, WJ ;

DAVANZO, JP ;

HELSLEY, GC ;

LUNSFORD, CD ;

TAYLOR, CR .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1015-&

[8]

WINBURY MM, 1957, ACTA PHYSIOL PHARM N, V5, P468