ENANTIOSPECIFIC SYNTHESIS OF AN AZIRIDINOBENZOAZOCINONE, AN ADVANCED INTERMEDIATE CONTAINING THE CORE NUCLEUS OF FR900482 AND FK973

被引：64

作者：

JONES, RJ ^{[1
]}

RAPOPORT, H ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 04期

关键词：

D O I：

10.1021/jo00291a010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A route to the enantiospecific synthesis of the aziridinobenzohexahydroazocine ketone 14, containing the core nucleus of FR900482 and FK973, has been developed. It consists of coupling the two key intermediates, sulfon-anilide 7 and methyl (2S,3S)-2,3-aziridino-4-hydroxy-butyrate 12, prepared from vinylglycine, followed by cyclization to the azocinone 14. © 1990, American Chemical Society. All rights reserved.

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页码：1144 / 1146

页数：3

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