Design and in vitro Evaluation of Mucoadhesive Microcapsules of Pioglitazone

被引：7
|
作者：
Singh, C. [1 ]
Jain, K. A. [1 ]
Kumar, C. [1 ]
Agarwal, K. [1 ]
机构：
[1] SD Coll Pharm & Vocat Studies, Bhopa Rd, Muzaffarnagar, UP, India
来源：
JOURNAL OF YOUNG PHARMACISTS | 2009年 / 1卷 / 03期
关键词：
Controlled release; microcapsules; mucoadhesive; orifice-ionic gelation method; pioglitazone; sodium alginate;
D O I：
10.4103/0975-1483.57063
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mucoadhesive microcapsules of pioglitazone were prepared using sodium alginate as a shell forming polymer and Carbapol 974, HPMC, Sodium CMC as a mucoadhesive polymer for the potential use of treating acute and chronic diabetes mellitus. Large spherical microcapsules with a coat consisting of sodium alginate and a mucoadhesive polymer could be prepared by orifice-ionic gelation process. The microcapsules exhibited good mucoadhesive properties and drug release from these mucoadhesive microcapsules was slow and extended over longer periods of time, depending on the composition of the coat. These mucoadhesive microcapsules are, thus, suitable for oral controlled release of pioglitazone.
引用
收藏
页码：195 / 198
页数：4
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