Design and in vitro Evaluation of Mucoadhesive Microcapsules of Pioglitazone

被引：7
|
作者：
Singh, C. [1 ]
Jain, K. A. [1 ]
Kumar, C. [1 ]
Agarwal, K. [1 ]
机构：
[1] SD Coll Pharm & Vocat Studies, Bhopa Rd, Muzaffarnagar, UP, India
来源：
JOURNAL OF YOUNG PHARMACISTS | 2009年 / 1卷 / 03期
关键词：
Controlled release; microcapsules; mucoadhesive; orifice-ionic gelation method; pioglitazone; sodium alginate;
D O I：
10.4103/0975-1483.57063
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mucoadhesive microcapsules of pioglitazone were prepared using sodium alginate as a shell forming polymer and Carbapol 974, HPMC, Sodium CMC as a mucoadhesive polymer for the potential use of treating acute and chronic diabetes mellitus. Large spherical microcapsules with a coat consisting of sodium alginate and a mucoadhesive polymer could be prepared by orifice-ionic gelation process. The microcapsules exhibited good mucoadhesive properties and drug release from these mucoadhesive microcapsules was slow and extended over longer periods of time, depending on the composition of the coat. These mucoadhesive microcapsules are, thus, suitable for oral controlled release of pioglitazone.
引用
收藏
页码：195 / 198
页数：4
相关论文
共 50 条
  • [31] Design and evaluation of controlled release mucoadhesive microspheres of amoxicillin for anti Helicobacter pylori therapy
    Venkateswaramurthy, N.
    Sambathkumar, R.
    Perumal, P.
    ASIAN JOURNAL OF PHARMACEUTICS, 2011, 5 (04) : 238 - 245
  • [32] Mucoadhesive controlled release microcapsules of indomethacin: Optimization and stability study
    Ibrahim, Hany M.
    Ahmed, Tarek A.
    Lila, Ahmed E. A.
    Samy, Ahmed M.
    Kaseem, Ala A.
    Nutan, Mohammad T. H.
    JOURNAL OF MICROENCAPSULATION, 2010, 27 (05) : 377 - 386
  • [33] Formulation and in vitro evaluation of a thermoreversible mucoadhesive nasal gel of itopride hydrochloride
    Marzouk, Maha A.
    Osman, Dina A.
    Abd El-Fattah, Amany, I
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2018, 44 (11) : 1857 - 1867
  • [34] Development and in vitro evaluation of mucoadhesive gelatin films for the vaginal delivery of econazole
    Dolci, Luisa Stella
    Albertini, Beatrice
    Di Filippo, Maria Francesca
    Bonvicini, Francesca
    Passerini, Nadia
    Panzavolta, Silvia
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 591
  • [35] Design and in vitro Biodegradation of Novel Hepatocyte-Targetable (Galactose Polycation/Hemoglobin) Multilayers and Microcapsules
    Zhang, Fu
    Liu, Li-Jun
    Wu, Qi
    Lin, Xian-Fu
    MACROMOLECULAR CHEMISTRY AND PHYSICS, 2009, 210 (12) : 1052 - 1060
  • [36] FORMULATION, OPTIMIZATION AND IN VITRO EVALUATION OF RAPID DISINTEGRATING AND MUCOADHESIVE SUBLINGUAL TABLETS OF LORAZEPAM
    Varshosaz, Jaleh
    Firozian, Farzin
    Ghassami, Erfaneh
    FARMACIA, 2015, 63 (02) : 234 - 246
  • [37] FORMULATION AND IN-VITRO EVALUATION OF MESALAMINE MUCOADHESIVE TABLETS FOR COLONIC DRUG DELIVERY
    Sahoo, Prabhat Kumar
    Das, Sujit
    Sahoo, Amaresh Chandra
    Kanungo, Sunil Kumar
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (10): : 4982 - 4990
  • [38] In vivo, in vitro evaluation of linseed mucilage based buccal mucoadhesive microspheres of venlafaxine
    Nerkar, Pankaj Padmakar
    Gattani, Surendra
    DRUG DELIVERY, 2011, 18 (02) : 111 - 121
  • [39] Preparation and in vitro evaluation of thermosensitive and mucoadhesive hydrogels for intranasal delivery of phenobarbital sodium
    Alami-Milani, Mitra
    Salatin, Sara
    Rayeni, Farzaneh Sharifi
    Jelvehgari, Mitra
    THERAPEUTIC DELIVERY, 2021, 12 (06) : 461 - 475
  • [40] Development, optimization and in vitro evaluation of alginate mucoadhesive microspheres of carvedilol for nasal delivery
    Patil, Sanjay B.
    Sawant, Krutika K.
    JOURNAL OF MICROENCAPSULATION, 2009, 26 (05) : 432 - 443
12345