Design and in vitro Evaluation of Mucoadhesive Microcapsules of Pioglitazone

被引：7
|
作者：
Singh, C. [1 ]
Jain, K. A. [1 ]
Kumar, C. [1 ]
Agarwal, K. [1 ]
机构：
[1] SD Coll Pharm & Vocat Studies, Bhopa Rd, Muzaffarnagar, UP, India
来源：
JOURNAL OF YOUNG PHARMACISTS | 2009年 / 1卷 / 03期
关键词：
Controlled release; microcapsules; mucoadhesive; orifice-ionic gelation method; pioglitazone; sodium alginate;
D O I：
10.4103/0975-1483.57063
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mucoadhesive microcapsules of pioglitazone were prepared using sodium alginate as a shell forming polymer and Carbapol 974, HPMC, Sodium CMC as a mucoadhesive polymer for the potential use of treating acute and chronic diabetes mellitus. Large spherical microcapsules with a coat consisting of sodium alginate and a mucoadhesive polymer could be prepared by orifice-ionic gelation process. The microcapsules exhibited good mucoadhesive properties and drug release from these mucoadhesive microcapsules was slow and extended over longer periods of time, depending on the composition of the coat. These mucoadhesive microcapsules are, thus, suitable for oral controlled release of pioglitazone.
引用
收藏
页码：195 / 198
页数：4
相关论文
共 50 条
  • [1] Design and development of gliclazide mucoadhesive microcapsules:: In vitro and In vivo evaluation
    Prajapati, S. K.
    Tripathi, Purnima
    Ubaidulla, Udhumansha
    Anand, Vikas
    AAPS PHARMSCITECH, 2008, 9 (01) : 224 - 230
  • [2] Design and Development of Gliclazide Mucoadhesive Microcapsules: In Vitro and In Vivo Evaluation
    S. K. Prajapati
    Purnima Tripathi
    Udhumansha Ubaidulla
    Vikas Anand
    AAPS PharmSciTech, 9
  • [3] Preparation and in vitro evaluation of mucoadhesive microcapsules of atenolol
    Swamy, P. V.
    Amit, Hada
    Shirsand, S. B.
    Hiremath, S. N.
    Raju, S. A.
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2007, 41 (04) : 358 - 364
  • [4] Design and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: A technical note
    K. P. R. Chowdary
    Y. Srinivasa Rao
    AAPS PharmSciTech, 4 (3)
  • [5] Mucoadhesive Microcapsules of Glipizide Formulated with Gum Kondagogu: In Vitro and In Vivo Evaluation
    Raparla, Rama K.
    Talasila, Eswara G. K. M.
    Mankala, Santhosh K.
    Mayuren, Candasamy
    LATIN AMERICAN JOURNAL OF PHARMACY, 2011, 30 (07): : 1253 - 1259
  • [6] PREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF VERAPAMIL
    Manna, Niranjan Kumar
    Kumar, Nikesh
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (03): : 664 - 670
  • [7] Preparation and Evaluation of Mucoadhesive Microcapsules Employing Olibanum Resin for Controlled Release of Aceclofenac
    Chowdary, K. P. R.
    Madhavi, B. L. R.
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (07) : 5175 - 5181
  • [8] PREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF SODIUM VALPROATE
    Manna, Niranjan Kumar
    Dinda, Subas Chandra
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (09): : 2463 - 2468
  • [9] Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Pioglitazone for Controlled Release
    Chowdary, K. P. R.
    Enturi, Veeraiah
    Jagadish, K. R.
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (08) : 3513 - 3516
  • [10] Development and evaluation of aceclofenac-loaded mucoadhesive microcapsules
    Mankala, Santhosh Kumar
    Korla, Appanna Chowdary
    Gade, Sammaiah
    JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH, 2011, 2 (04) : 245 - 254
12345