DECOMPOSITION OF N-(2-CHLOROETHYL)-N-NITROSOUREAS IN AQUEOUS-MEDIA

被引:86
|
作者
MONTGOMERY, JA [1 ]
JAMES, R [1 ]
MCCALEB, GS [1 ]
KIRK, MC [1 ]
JOHNSTON, TP [1 ]
机构
[1] SO RES INST,KETTERING MEYER LAB,BIRMINGHAM,AL 35205
关键词
D O I
10.1021/jm00240a007
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:568 / 571
页数:4
相关论文
共 50 条
  • [1] Nitric oxide release by N-(2-chloroethyl)-N-nitrosoureas: a rarely discussed mechanistic path towards their anticancer activity
    Sarkar, Amrita
    Karmakar, Subhendu
    Bhattacharyya, Sudipta
    Purkait, Kallol
    Mukherjee, Arindam
    RSC ADVANCES, 2015, 5 (03) : 2137 - 2146
  • [2] Reaction of N-(2-chloroethyl)-N-nitrosoureas with DNA: Effect of buffers on DNA adduction, cross-linking, and cytotoxicity
    Chen, FX
    Bodell, WJ
    Liang, GN
    Gold, B
    CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (01) : 208 - 214
  • [3] Nitric oxide release by N-(2-chloroethyl)-N-nitrosoureas: A rarely discussed mechanistic path towards their anticancer activity
    Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata Mohanpur, Nadia Pin-West Bengal
    741246, India
    RSC Adv., 3 (2137-2146):
  • [4] Antineoplastic activity of 19-nortestosterone-linked N-(2-chloroethyl)-N-nitrosoureas against experimental prostate carcinoma in rats
    Tang, W
    Schneider, MR
    Eisenbrand, G
    ANNALS OF ONCOLOGY, 1998, 9 : 31 - 31
  • [5] SYNTHESIS AND CHARACTERIZATION OF STEROID-LINKED N-(2-CHLOROETHYL)NITROSOUREAS
    EISENBRAND, G
    FISCHER, J
    MUHLBAUER, K
    SCHIED, G
    SCHREIBER, J
    TANG, WC
    ZELEZNY, O
    ARCHIV DER PHARMAZIE, 1989, 322 (12) : 863 - 872
  • [6] tert-Butyl N-[N,N-bis(2-chloroethyl)sulfamoyl]-N-(2-chloroethyl)carbamate
    Seridi, Achour
    Akkari, Hocine
    Winum, Jean-Yves
    Benard-Rocherulle, Patricia
    Abdaoui, Mohamed
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2543 - +
  • [7] Synthesis and cytotoxic activity of N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates
    Botyánszki, J
    Bódi, J
    Stratford, IJ
    Süli-Vargha, H
    ANTI-CANCER DRUGS, 1999, 10 (10) : 903 - 909
  • [8] Theoretical investigation of the decomposition mechanisms of N-(2-chloroethyl)-N-nitrosourea
    Chun-Lin Lv
    Yong Dong Liu
    Ru Gang Zhong
    Theoretical Chemistry Accounts, 2007, 118 : 973 - 978
  • [9] Theoretical investigation of the decomposition mechanisms of N-(2-chloroethyl)-N-nitrosourea
    Lv, Chun-Lin
    Liu, Yong Dong
    Zhong, Ru Gang
    THEORETICAL CHEMISTRY ACCOUNTS, 2007, 118 (5-6) : 973 - 978
  • [10] Thermal decomposition mechanism of aromatic N-nitrosoureas
    Tanno, M
    Sueyoshi, S
    Miyata, N
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U1165 - U1165