Vascular disaggregation effects on erythrocytes in patients with arterial hypertension with abdominal obesity

The high incidence of thrombosis in patients with arterial hypertension with abdominal obesity is determined by the development of their manifestations of vasopathy. In view of the high prevalence in the developed countries of the combination of arterial hypertension with abdominal obesity, it is very important for science and practice to maintain the level of the state with this pathology of the level of vascular control over the process of aggregation by the most numerous population of blood cells - erythrocytes. The aim of the work is to clarify the state of this pathology of disaggregation capacity of blood vessels in relation to erythrocytes in patients with arterial hypertension with abdominal obesity. 55 patients with arterial hypertension of the 1st and 2nd degree with abdominal obesity of the second adult age were examined. The control group is represented by 26 clinically healthy persons of the second adulthood. Biochemical, hematological and statistical methods of investigation were used in the work. In patients under observation, an increase in the amount of cholesterol in erythrocyte membranes, a decrease in the level of total phospholipids in them, and an increase in the processes of lipid peroxidation were found. Increased activity of spontaneous aggregation of erythrocytes was noted in patients. This was accompanied in all patients by a decrease in vascular control over this process. The attenuation of disaggregating vascular control over spontaneous aggregation of erythrocytes should be considered as a consequence of metabolic abnormalities arising in arterial hypertension with abdominal obesity, increased vasospasm and active lipid peroxidation. The found vasopathy in this contingent of patients sharply increased their risk of thrombosis, which can lead to disability and death.