TRUE HISTIOCYTIC LYMPHOMA - A STUDY OF 12 CASES BASED ON CURRENT DEFINITION

被引：28

作者：

KAMEL, OW

GOCKE, CD

KELL, DL

CLEARY, ML

WARNKE, RA

机构：

[1] Department of Pathology, Stanford University Medical Center, Stanford, CA

[2] Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 1-2期

关键词：

TRUE HISTIOCYTIC LYMPHOMA; DEFINITION;

D O I：

10.3109/10428199509064926

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

True histiocytic lymphoma (THL), as it is currently defined, is a rare entity. We report 12 cases of THL seen at Stanford over the last ten years. By definition, the neoplastic cells in each case showed histological and immunological evidence of histiocytic differentiation. Seven females and five males ranged in age from 9 to 67 years. Sites of involvement included lymph node, soft tissue, bone, stomach, small intestine, mediastinum, kidney, breast and salivary gland. Lymph nodes showed diffuse architectural effacement and/or a paracortical pattern of involvement. The infiltrates involved other tissues in a diffuse pattern. Cytologically the cells were characterized by abundant eosinophilic cytoplasm and enlarged, indented eccentrically placed nuclei containing prominent nucleoli. In all cases the cytological features were sufficiently atypical to indicate a neoplastic infiltrate, Paraffin section immunophenotyping demonstrated reactivity of the atypical cells for CD15, 43, 45RO, 45RB, 68, lysozyme and/or S100. In frozen sections, the atypical cells demonstrated reactivity for CD4 (cytoplasmic), 11c, 14, 15, and/or 68, Genotypic studies were performed on 3 cases, one of which showed rearrangements of immunoglobulin heavy and light chain genes. Follow-up was available on eleven patients, six of whom died of disease 0.5 to 36 months following diagnosis.

引用

页码：81 / 86

页数：6

共 11 条

[1]

Hanson C.A., Jaszcz W., Kersey J.H., Magdalena A.G., Peterson B.A., Fajl-Peczalska K.J., Frizzera G., True histiocytic lymphoma: histopathologic, immunophenotypic and genotypic analysis, Br. J. Haematol, 73, pp. 187-198, (1989)

[2]

Levine E.G., Hanson C.A., Jaszcz W., Peterson B.A., True histiocytic lymphoma, Sem. Oncol, 18, pp. 39-49, (1991)

[3]

Franchino C., Reich C., Distenfeld A., Ubriaco A., Knowles D.M., A clinicopathologically destinctive primary splenic histiocytic neoplasm: demonstration of its histiocytic derivation by immunophenotypic and molecular genetic analysis, Am. J. Surg. Pathol, 12, pp. 398-404, (1988)

[4]

Ralfkiaer E., Delsol G., O'Connor N.T.J., Malignant lymphomas of true histiocytic origin. A clinical, histological, immunophenotypic and genotypic study, J. Pathol, 160, pp. 9-17, (1990)

[5]

Milchgrub S., Kamel O.W., Wiley E., Malignant histiocytic neoplasms of the small intestine, Am. J. Surg. Pathol, 16, pp. 11-20, (1992)

[6]

Miettinen M., Fletcher C.D., Lasota J., True histiocytic lymphoma of the small intestine. Analysis of two S100 protein-positive cases with features of interdigitating reticulum cell sarcoma, Am. J. clin. Pathol, 100, pp. 285-292, (1993)

[7]

Bindl J.M., Warnke R.A., Advantages of detecting monoclonal antibody binding to tissue sections with biotin and avidin reagents in coplin jars, Am. J. Clin. Pathol, 85, pp. 490-493

[8]

Cleary M.L., Chao J., Warnke R., Sklar J., Immunoglobulin gene rearrangement as a diagnostic criterion of B cell lymphoma, Proc. Natl. Acad. Sci. U.S.A, 81, pp. 593-597, (1984)

[9]

Ohyashiki J.H., Ohyashiki K., Yoyama K., T-cell receptor gene rearrangement and its expression in human myeloid leukemia cell lines, Cancer Genet. Cytogenet, 31, pp. 193-200, (1989)

[10]

Sheibani K., Wu A., Ben-Ezra J., Rearrangement of K-chain and T-cell receptor B-chain genes in malignant lymphomas of “T-cell” phenotype, Am. J. Pathol, 129, (1987)

← 1 2 →