ABROGATION OF SUPPRESSOR CELLS ACTIVITY BY CIS-DIAMMINEDICHLOROPLATINUM (CDDP) TREATMENT USING THERAPEUTIC DOSES IN OVARIAN-CANCER PATIENTS

被引：7

作者：

TSUDA, H

KITAHASHI, S

UMESAKI, N

KANAOKA, Y

KAWABATA, M

OGITA, S

机构：

[1] OSAKA CITY UNIV,SCH MED,DEPT OBSTET & GYNECOL,OSAKA 545,JAPAN

[2] OSAKA CITY UNIV,SCH MED,DEPT CLIN CENT LAB,OSAKA 545,JAPAN

来源：

GYNECOLOGIC ONCOLOGY | 1994年 / 52卷 / 02期

关键词：

D O I：

10.1006/gyno.1994.1034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the activity of natural killer (NK) cells and suppressor cells and the population of peripheral blood lymphocytes before and after cis- diamminedichloroplatinum (CDDP) treatment using therapeutic doses in 15 ovarian cancer patients. CDDP did not decrease NK cell activity but selectively abrogated suppressor cell activity up to 7 days after treatment (P < 0.05). The CD56+ CD16+ cell and CD8+ CD11+ T cell populations significantly decreased; however, the CD4+ 2H4+ T cells, showed a significant increase after treatment (P < 0.05). We conclude that CDDP treatment using therapeutic doses could selectively abrogate suppressor cell activity. © 1994 Academic Press, Inc.

引用

页码：218 / 221

页数：4

共 21 条

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[2]

BAGASRA O, 1985, CANCER IMMUNOL IMMUN, V19, P142

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