SYNTHESIS AND BIOLOGICAL EVALUATIONS OF N-(2-SUBSTITUTED-1-CARBOXYL) VINYLAZETIDINONES - A STUDY ON THE ESSENTIAL STRUCTURAL ELEMENT FOR BIOLOGICAL-ACTIVITIES OF BETA-LACTAM ANTIBIOTICS

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作者
KANG, HY
PAE, AN
KOH, HY
CHANG, MH
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O6 [化学];
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0703 ;
摘要
A series of compounds, N-(2-substituted-1-carboxy)vinylazetidinones were successfully synthesized in order to test the hypothesis that biological activities of beta-lactam antibiotics could be attributed to the smooth flow of electrons after a nucleophilic attack at the carbonyl carbon in the beta-lactam ring. After introduction of aminothiazolylacetamido group at 3-position of the azetidinones, their biological activities were evaluated. Their low activities led to the conclusion that the smooth electron flow in beta-lactams in not the sufficient source for the biological activities.
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页码:75 / 79
页数:5
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