2 TYPES OF QUISQUALATE RECEPTORS ARE DECREASED IN HUMAN OLIVOPONTOCEREBELLAR ATROPHY CEREBELLAR CORTEX

被引：14

作者：

MAKOWIEC, RL

ALBIN, RL

CHA, JHJ

YOUNG, AB

GILMAN, S

机构：

[1] UNIV MICHIGAN,DEPT NEUROL,NEUROSCI LAB BLDG,1103 E HURON,ANN ARBOR,MI 48104

[2] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48104

来源：

BRAIN RESEARCH | 1990年 / 523卷 / 02期

关键词：

Cerebellar cortex; Olivopontocerebellar atrophy; Purkinje cell; Quisqualate; α-Amino-3-hydroxy-5-methylisoxazole-4-propionate;

D O I：

10.1016/0006-8993(90)91504-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We used receptor autoradiography to study the distribution of ionotropic and metabotropic quisqualate (QA) receptors in normal human cerebellar cortex and cerebellar cortex from 7 cases of olivopontocerebellar atrophy (OPCA). In normal human cerebellar cortex, both types of QA receptors were densest in the molecular layer. Both ionotropic and metabotropic QA receptors were significantly diminished in the molecular layer of OPCA specimens. These results suggest that both ionotropic and metabotropic QA receptors are localized on Purkinje cell dendrites. © 1990.

引用

页码：309 / 312

页数：4

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