3-DIMENSIONAL STRUCTURE OF A MONOCLONAL-ANTIBODY FAB FRAGMENT AGAINST CD5

被引：0

作者：

GUARNE, A ^{[1
]}

BRAVO, J ^{[1
]}

CALVO, J ^{[1
]}

LOZANO, F ^{[1
]}

VIVES, J ^{[1
]}

FITA, I ^{[1
]}

机构：

[1] HOSP CLIN BARCELONA, SERV IMMUNOL, E-08036 BARCELONA, SPAIN

来源：

ANALES DE QUIMICA-INTERNATIONAL EDITION | 1995年 / 91卷 / 3-4期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have solved the crystal structure of a monoclonal antibody Fab fragment (CRIS-1) against CD5, a T-lymphocite membrane protein, at 2.4 Angstrom of ressolution by X-ray diffraction studies. This monoclonal antibody is able to simulate the biological effect of CD72, a B-lymphocite surface protein, the ligand of CD5. The molecule crystallized in the space group p2(1)2(1)2(1), with cell parameters a = 37.39 Angstrom, b = 86.75 Angstrom, c = 134.77 Angstrom and alpha = beta = gamma = 90 degrees. Tridimensional structure was solved by the molecular replacement method. Crystals have a very compact packing with multiple intermolecular contacts.

引用

页码：296 / 299

页数：4

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